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z7413WP - Demystifying Accuracy in Life Sciences Instrumentation

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When evaluating a syringe pump as part of the error analysis of an instrument, "accuracy" is often less important than repeatability. Accuracy is defined by the average amount of fluid a syringe delivers over multiple operations. If those individual amounts vary widely, i.e. the precision of the the pump is low, overall instrument error is increased. Thus, a very "accurate" but low precision device is much harder to control than a device with high precision that is less accurate. This is because, given a high level of precision, calibration of the fluid circuit will result in high repeatability and a reliable instrument (see figure 5). The bottom line is that most OEM designers want the same action to produce the same result reliably time after time (see figure 6), which drives them to prioritize precision in syringe pumps. On the other hand, accuracy can become as important as precision for OEMs when the goal is to establish a single calibration to achieve dispenses of various volumes, or a highly stable flow pattern (see figure 7). Conclusion Before calibration After calibration Figure 5. 250 230 210 190 170 150 130 110 90 70 50 6.2 6.3 6.4 6.5 6.6 6.7 6.8 6.9 7 7.1 7.2 Flow µl/min Time (sec) Figure 7. 1000 1200 1000 800 800 600 600 400 400 200 200 0 0 Measured (µL) Measured (µL) Figure 6. actual target white paper 05

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